Highlights
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Mechanism of ciliary train switch and cargo recognition
A study by the Pigino Group at Human Technopole reveals that the conversion from anterograde to retrograde intraflagellar transport requires the complete disassembly of anterograde trains at the ciliary tip and provides the mechanisms for direction-specific cargo binding and transport in cilia.
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Chan Zuckerberg Initiative grant to the Glastonbury Group
The Glastonbury Group is among the recipients of the Data Insights Cycle 3 awards. The aim of the grant is to develop a machine learning model that identifies disease-relevant cell subpopulations whilst predicting a phenotype/disease of interest from large-scale single-cell RNA-seq data.
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The National Facility for Structural Biology with Paolo Swuec
Meet Paolo Swuec, responsible for running the Italy’s first Cryo-EM Facility and, today, Head of the National Facility for Structural Biology at Human Technopole: a hub for cutting-edge research, facilitating the structural characterization of biological entities, ranging from tissues to amino acid side-chains.
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Understanding the pathogenesis of SARS-CoV-2 encephalitis
In collaboration with an international team of scientists, HT researchers identified a missense mutation in a gene involved in brain-intrinsic immunity as the genetic cause of SARS-CoV-2 brainstem encephalitis.
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HT’s “Open” Technologies for the Italian Scientific Community
Human Technopole is opening its National Facilities, providing advanced equipment and technologies accessible through calls for proposals open to the Italian scientific community. Projects will be selected by a commission of international experts. Scientists will have access to five new dedicated facilities, which act as catalysts for open innovation in the life sciences sector, crucial for research and the health of Italians.
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New Human Technopole Strategic Plan 2024-2028 now online!
Five years since its inception, Human Technopole is now a dynamic institute where researchers from around the world have laid the foundations for unravelling the fundamental mechanisms of life across multiple biological scales – molecules, cells, tissues, organs, organisms, populations – in space and time.
Research at HT
Improving human life and technology by investing in human health and prevention research is the ultimate goal of Human Technopole. We need to prevent and cure diseases to allow people of all ages to not only live longer, but also live better.
To accomplish its mission, HT’s research strives to unravel fundamental mechanisms relevant to human physiology and disease using a multi-scale systems biology approach, based on a combination of experimental research and theory, coupled with computational biology and Artificial Intelligence.
Shared Research Infrastructure
To fulfil the needs of the Italian life science research community, HT infrastructure includes 5 National Facilities, serving as technological hubs and incubators for developing and disseminating new tools and methodologies and for carrying out top-level research.
Courses and Conferences
Work with us
We offer the opportunity to be part of a new, dynamic research institute promoting a highly collaborative and international working environment.
We aim to attract the best resources in each field with a selection based on merit and transparency as we believe that highly diverse teams produce the best and most innovative results.
If you are a passionate person who likes to seize great challenges, consider applying for one of our scientific or administrative vacancies.